Similarly looking forward to Fallout 3, Left 4 Dead, Alan Wake- but also think the new Alone in the Dark could be promising. They've modelled Central Park in NY quite painstakingly and have some really fancy new fire effects where the flames will propigate realistically and spread across wooden surfaces etc. Also some quite inventive weapon systems in which you can combine various bits and peices to improvise weapons. I remember the origional series fondly so we shall see if they do it justice.
Also on my to buy list, but not on your clicky list is Borderlands- a Mad Max esque free-form shooter with some great scope for co-op play. Similar look to ID's Rage but here your buggy is more transport less racing (i hope). They're aiming for an rpg feel with a bunch of item drops and customisable weapons. Driving about a desert with 3 mates in your buggy sounds promising.
On the adventure side of things there's Vampyre story from some of the ex-lucasarts staff and American McGees Grimm, a 24 part adventure retelling classic fairy stories in American's trademark dark stylee- I just loved the atmosphere of Alice when it came out, though 24 parts? Will have to be very good or very cheap for me to buy something more than a few times over.
Oh, and Duke Nukem Forever cos as we all know its about to be released, honest! Ahmmm I'll believe it when i see it 3D Realms! 
Also watching closely Bionic Commando and Speedball... cos i loved the origionals, Brutal Deluxe ftw! oh and Dragon Age looks awesome but Im guessing 2009+
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Anyhoo, after taking part in the Beta I can safely say I will not be buying it. It's a horrible mish-mash of Battlefield 2142 and ET:QW.
